CHINESE ACADEMY OF SCIENCES;GUANGZHOU INSTITUTE OF BIOMEDICINE AND HEALTH
发明人:
DING, KE,CHANG, SHAOHUA,XU, SHILIN,ZHANG, LIANWEN,TU, ZHENGCHAO,DING, JIAN,GENG, MEIYU,CHEN, YI
申请号：
CA2838885
公开号：
CA2838885A1
申请日:
2011.12.21
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Provided are 7-substituted amino-3, 4-2H-pyrimidine[4,5-d] pyridine-1H-one compounds represented by general formula (I) or (II) and their uses for preparing drugs for treating cancers. Researches have proved that they can inhibit the proliferation of many kinds of tumor cells and target to inhibit epidermal growth factor receptor kinase (EGFR), especially inhibit cancer cells of EGFR (T790M) mutant with single-point mutant or multi-points mutant. Therefore, they can be used as EGFR inhibitors for anti-cancer drugs, and possesses excellent value for uses.
