A wound treatment appliance is provided that generally comprises animpermeableflexible overlay that covers all or a portion of a wound for purposes ofapplying a reducedpressure to the covered portion of the wound. When reduced pressure is appliedto the flexibleoverlay, it collapses in the approximate direction of the wound, producing anapproximatelyhermetic seal between the flexible overlay and the body in the area of thewound. In addition,the appliance may further comprise a collection chamber to collect and storeexudate from thewound. The appliance may also comprise a vacuum system to supply reducedpressure to thewound in the area under the flexible overlay. Further, the appliance mayinclude wound packingmeans to assist in wound healing. The appliance may also include a suctiondrain. Finally,methods are provided for using the appliance.