PIRYMIDYNA PODSTAWIONA TIAZOLEM LUB IMIDAZOLEM, AMIDOWE POCHODNE PIRAZYNY I PIRYDYNY I POWIĄZANE ZWIĄZKI TAKIE JAK INHIBITORY ABL1, ABL2 I BCR-ABL1 DO LECZENIA NOWOTWORU, SPECYFICZNYCH INFEKCJI WIRUSOWYCH I SPECYFICZNYCH ZABURZEŃ CNS
FURET, PASCAL,GROTZFELD, ROBERT MARTIN,JONES, DARRYL BRYNLEY,MANLEY, PAUL,MARZINZIK, ANDREAS,MOUSSAOUI, SALIHA,PELLE, XAVIER FRANCOIS ANDRE,SALEM, BAHAA,SCHOEPFER, JOSEPH,JAHNKE, WOLFGANG
申请号：
PL13730654
公开号：
PL2900637T3
申请日:
2013.05.09
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
The present invention relates to compounds of formula I: in which Y, Y1, Y4, Y5, Y6, R1, R2, R3 and R4 are defined in the Summary of the Invention； capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
