A humanized antibody comprising an H chain complementarity determining region comprising the amino acid sequence represented by SEQ ID NOs: 1 to 3 and an L chain complementarity determining region comprising the amino acid sequence represented by SEQ ID NOs: 4 to 6. The humanized antibody of the present invention is a humanized antibody that has an activity of specifically binding to structurally altered transthyretin (TTR) and an activity of inhibiting TTR fibrosis, and is suitable for application to the human body. is there.配列番号１～３で示されるアミノ酸配列からなるＨ鎖の相補性決定領域と、配列番号４～６で示されるアミノ酸配列からなるＬ鎖の相補性決定領域とを含む、ヒト化抗体。本発明のヒト化抗体は、構造変化を起こしたトランスサイレチン（TTR）へ特異的に結合する活性やTTRの線維化を阻害する活性を有し、人体への適用に適したヒト化抗体である。
