The present invention provides highly purified omega-3 fatty acidformulations. Certain formulations providedherein have contain greater than 85% omega-3 fatty acids by weight. Certainother formulations provided herein contain EPA andDHA in a ratio of from about 4.01: 1 to about 5:1. The invention also providesmethods of using the dosage forms to treat a varietyof cardiovascular, autoimmune, inflammatory, and central nervous systemdisorders by administering a formulation of the inventionto a patient in need thereof.