It comprises a mixture of lidocaine, prilocaine and tetracaine, or theirpharmaceutically acceptable salts. The preferred composition comprises thefollowing components in the indicated approximate w/w percentages: 1.5% oflidocaine base； 1.5% of prilocaine base； 4% of tetracaine base； 10% ofmethylpyrrolidone； 2% of dimethyl sulfoxide； 0.08% of topical hyaluronidase；1.5% of guar gum； 1 % of Tween-20； 0.5% of Tween-80, and the necessary amountof water to 100%. It exhibits a a high concentration on skin, a deepanesthetic effect and a significantly more rapid onset of the anestheticeffect than comparable transdermal anesthetics.
