It is used as an inhibitor of 17b-hsd1 and to treat or prevent diseases or disorders caused by steroid hormones, such as those caused by the need to inhibit enzyme 17b-hsd1 and / or steroid hormones that reduce the endogenous concentration of estradiol. In addition, it is also related to the preparation and composition of the above compounds.2. Pharmacist who contains one or more of the above compounds or acceptable salts on their drugs as active ingredients. 1. Claim 1: a compound of formula (1), wherein (I-A) R2 and r830808 are selected from group H respectively；halogen, C₁₋₆ alkyl,Halogenated tar c83218323；perhaloalkyl C₁₋₃,CN, NO₂,8323,N (R)(CH) N (R)o. (ch8322or) 8345or, co8322； R, conhr, nhcor, SCOR or cor； R3 was selected from group H, tar c832318326；Halogenated tar c83218323；perhaloalkyl C₁₋₃,N (R) N y ORR3: from R, bencilo, sucinilo, glucuni, acid, saturated heterocyclic ring, composed of 5 to 6 members, composed of 1 to 2 heteroatoms selected independently from N and O (ch832228345oh, so8322)； Oh, so8322； R, tocilo, so8322； (R) 832222；PO (OR)C (O) N (R)C (O) (CH) N (R)C (o) r； O (I-B) R2 and R3 or r83088；Together with the carbon atoms in the ring, they form an aperiodic ring of five unsaturated or aromatic members, consisting of one to two heteroatoms independently selected from n, or replaced by methyl or oxo； and r8308o or R2,respectively, it is H and； (ii-a) one of R⁷ and R⁸ is OR⁷,where R⁷ is selected from the group consisting of H or C₁₋₆ alkyl and the other is selected from the group consisting of H, C₁₋₆ alkyl,Halogenated tar c83218323；perhaloalkyl C₁₋₃,C₂₋₆ alkenyl,1. C 83228331 asphalt；bencilo (CH) CN (CH) OH N (R)(CH) N (R)C (O) OR (CH) C (O) OR C (O) N (R)(CH) C (O) NHOr8311th,COR, nhco asphalt c83321262；-COCH O-P (O) (OH)or (ii-b) one of R⁷ and R⁸ is H and the other is selected from the group consisting of halogen, C₁₋₃ haloalkyl,perhaloalkyl C₁₋₃,(CH) CN OSO OH OSO R O-tosilo OC (O) R OC (O) (CH) COOR OC (O) (CH) N (R)OC (O) CH NHC (O) OR OPO
