Werner Goebel;Ivaylo Nikolov Gentschev;Joachim Fensterle;Ulf R. Rapp
发明人:
Ivaylo Nikolov Gentschev,Joachim Fensterle,Ulf R. Rapp,Werner Goebel
申请号：
US11939254
公开号：
US08669091B2
申请日:
2007.11.13
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A Escherichia, Salmonella, Yersinia, Vibrio, Listeria, Shigella, or Pseudomonas bacterium that has the following components: (I) a polynucleotide encoding a heterologous antigenic determinant that induces a CTL response against a tumor cell； (II) a polynucleotide encoding a heterologous protein toxin or toxin subunit； and (III) (a) a polynucleotide encoding a transport system that expresses the products of (I) and (II) on the outer surface of the bacterium or that secretes products of (I) and (II) from the bacterium； and (IV) a polynucleotide that activates the expression of one or more of (I). (II), and/Or (III) in the bacterium wherein polynucleotides (I), (II), (III) and (IV) are different from each other and polynucleotides (I), (II) and (III) encode proteins that are different from each other.
