GRANDEA, ANDRES, G,KING, GORDON,COX, THOMAS,OLSEN, OLE,MITCHAM, JENNIFER,MOYLE, MATTHEW
申请号：
NZ58550008
公开号：
NZ585500A
申请日:
2008.11.12
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is isolated fully human monoclonal antibody, wherein said monoclonal antibody has the following characteristics: (a) specifically binds to a non-linear epitope in the ectodomain (M2e) of the matrix 2 (M2) tetrameric protein of an influenza virus (b) specifically binds to a non-linear epitope of influenza A on infected cells and (c) specifically binds to a non-linear epitope of the influenza A virus, wherein said epitope includes the amino acid sequence SLLTEV (SEQ ID NO: 42) and wherein the antibody specifically binds to the non-linear epitope with an affinity constant Ka of greater than or equal to 104 M-1 .
