The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defences. One embodiment of the present invention is the use of non-replicatingL. johnsoniiLal NCC533 (deposit number CNCM I-1225) for use in the treatment or prevention of disorders related to the immune system including infections.本發明大體係關於預防及/或治療發炎及傳染性疾病之領域,特定言之係藉由加強內源性抗微生物防禦。本發明之一實施例係非複製性約氏乳桿菌(L. johnsonii)Lal NCC 533(寄存號CNCM I-1225)用於治療或預防與免疫系統相關的疾病(包括感染)之用途。