CORKEY BRITTON,NOTTE GREGORY,ZABLOCKI JEFF,CORKEY Britton,NOTTE Gregory,ZABLOCKI Jeff
申请号：
SI201130521
公开号：
SI2588475T1
申请日:
2011.06.30
申请国别(地区):
SI
年份:
2015
代理人:
摘要：
The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, R, R1, R2 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
