The Regents of the University of Colorado; a body Corporate
发明人:
Abigail L. Reens,Amy L. Crooks,Corrella S. Detweiler
申请号：
US16497315
公开号：
US20200022961A1
申请日:
2018.03.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
An empirical Screen for Anti-infectives using Fluorescence microscopy of IntracellulaR Enterobacteriaceae (SAFIRE) was developed. Using this methodology, a library of small molecules and identified antimicrobials that are cell permeable and non-host-toxic were screened. Inhibitors of bacterial efflux pumps were identified as being implicated in antibiotic resistance and are attractive therapeutic targets for antimicrobials.
