THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A CAROLINA HEALTHCARE SYSTEM
发明人:
SCHRUM, LAURA W.,LAKNER, ASHLEY M.
申请号：
CA2844197
公开号：
CA2844197A1
申请日:
2012.08.03
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides a method for treating or preventing fibrosis comprising administering to a patient in need of such treatment or prevention an amount of microRNA-19b effective to treat or prevent said fibrosis. In some embodiments, the invention relates to inhibiting the activation of collagen-producing cells and thereby treating or preventing fibrosis. The methods of the invention also include detection of biomarkers that can be used to diagnose disease and/or evaluate the prognosis of a patient suffering from fibrosis or at risk of developing fibrosis, such as hepatic fibrosis. Such methods may be used to characterize the progression of diseases associated with fibrosis.
