For an electrosurgical instrument of ablating biological tissue, the instrument including the tissue-contacting layer medical device having: a microwave power source 134 includes the power amplifier 152 for generating the microwave energy for ablating biological tissue The sum for being connected to microwave power source 134 is configured to microwave energy be given the radiating structure of biological tissue. Power amplifier 152 may include a wide band gap semiconducter transistor and/or the high electron mobility transistor (HEMT) of a GaN. Microwave power source 134 may include a power amplifier drive generator circuitry 132. Generator circuitry 132 may include: the oscillator for being arranged and receiving a direct-flow input signal and generating a microwave frequency signal One exciting amplifier 148, which is arranged, to be received microwave frequency signal and generates the input signal for power amplifier 152. Tissue treatment part may include a power supply, it preferably includes a coupling unit inductively or the coupling power magnetically from external supply. Power amplifier 152 may be coupled to radiating structure by the adjustable transmission line with an adjustable electrical length. Tissue treatment part can form a distal end and assemble, and be used to determine the insertion of the one-shot measurement pipeline of such as one endoscope of equipment by the range of a surgery.