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СИНТЕЗ МЕЗИЛАТА 1-АМИНО-1,3,3,5,5-ПЕНТАМЕТИЛЦИКЛОГЕКСАНА
专利权人:
MERTS FARMA GMBKH UND KO. KGAA
发明人:
KHENRIKH MARKUS,ХЕНРИХ Маркус,NEGURA SIMONA,НЕГУРА Симона,TASHI GERGEJ,ТАШИ Гергей,KOCHAN POL,КОЧАН Пол,SBROGIO FEDERIKO,СБРОГИО Федерико,PIERIN MIKHAEHL,ПИЕРИН Михаэль,KOLLER KHERBERT,КОЛЛЕР Херберт
申请号:
RU2011146633/04
公开号:
RU0002513090C2
申请日:
2010.04.16
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: claimed compound can be used in case of diseases and states, such as tinnitus, neuropathic pain and in treatment of Alzheimers diseases. Method includes stage (1): interaction of 1-amino-1,3,3,5,5-pentamethylcyclohexane with methanesulfonic acid in anisole at temperature from 50°C to 100°C and ratio of anisole volume to weight of 1-amino-1,3,3,5,5-pentamethylcyclohexane from 5 to 15 ml of anisole per gram of 1-amino-1,3,3,5,5-pentamethylcyclohexane. Solvent can contain dissolved in it water. Metod can also include stage (ii): separation of 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate from reaction mixture of stage (i) by crystallisation with decrease of temperature in the range from -20°C to 50°C. Additionally, after stage (i) or stage (ii), method can include at least one of stages (iii)-(v). Stage (iii) consists in recrystallisation of product, formed at stage (i) or stage (ii) from anisole stage (iv) includes addition of 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate at any of preceding stages (i)-(iii) and stage (v) ingludes deagglomeration and/or crushing product, formed at any of preceding stages (i)-(iv). Crystals, obtained at stage (iv) are star-shaped. At stage (ii) or at stage (iv) also obtained are particles of 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate, where less than 15% in weight of particles have particle size 10 mcm and less or where less than 10% in weight of particles have particle size 10 mcm and less. Before separation of 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate, mixture, obtained at stage (i), (ii) or (iii), is usually cooled to room temperature or below room temperature at rate of cooling from 0.05°C/min to 2°C/min.EFFECT: invention relates to improved method of obtaining 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate.11 cl, 6 dwg, 2 tbl, 22 exИзобретение относится к улучшенному способу получения мезилата 1-амино-1,3,3,5,5-пентаметилциклогексана. Указанное соединение может быть использов
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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