THE PRESENT INVENTION INCLUDES COMPOSITIONS AND DRYING METHODS FOR PRESERVING SENSITIVE BIOACTIVE MATERIALS, SUCH AS PEPTIDES, PROTEINS, HORMONES, NUCLEIC ACIDS, ANTIBODIES, DRUGS VACCINES, YEAST BACTERIA (PROBIOTIC OR OTHERWISE), VIRUSES AND/OR CELL SUSPENSIONS, IN STORAGE. THE COMPOSITIONS INCLUDE A CARBOHYDRATES COMPONENT AND A GLASS ENHANCER COMPONENT, WHEREIN THE CARBOHYDRATE COMPONENT INCLUDES A MIXTURE OF DI-, OLIGO AND POLYSACEHARIDES AND THE GLASS ENHANCER INCLUDES IONS OF ORGANIC ACID AND PROTEIN HYDROLYSATES. THE COMPOSITION IS PREPARED BY DISPERSING ALL THE SOLID COMPONENTS IN A SOLUTION AND THEN SNAP-FROZEN TO FORM SMALL BEADS, STRINGS OR DROP LETS. THE PREFERRED DRYING METHOD OF THE FROZEN BEADS, STRINGS OR DROPLETS IS INITIATED BY A SHORT PURGING AND STRUCTURE STABILIZING STEP OF THE FROZEN PARTICLES UNDER A VACUUM PRESSURE OF LESS THAN <；2000 MTORR FOLLOWED BY A PRIMARY DRYING STEP UNDER VACUUM PRESSURE OF MORE THAN >；2000 MTORR AND AT A DESIRED TEMPERATURE. DURING THE SECONDARY AND FINAL DRYING STEP OF THE MATERIAL A FULL VACUUM PRESSURE AND ELEVATED TEMPERATURE ARE APPLIED, TO ACHIEVE A FINAL DESIRABLE WATER ACTIVITY OF THE DRY MATERIAL.
