First compound that activates a receptor formaciPrimer compound activates a receptor selected training TRPV1 channels, P2X (2/3), TRPón selected TRPV1 channels, P2X (2/3), TRPA1 yTRPM8 which is present in nociceptors and / or prA1 yTRPM8 which is present in nociceptors and / or pruriceptores, and a second compound that inhibits unouriceptores, and a second compound that inhibits one or ionic máscanales regulated voltage when or ionic máscanales regulated voltage when applied to the inner face of said per channel it is applied to the internal face of said channels but not inhibesustancialmente said channels when so not inhibesustancialmente said channels when applied to the external face of said channels for and applied to the external face of said channels for use in a detratamiento method pain or picorsu detratamiento use in a method of pain or itch in a patient, wherein said second compound in a patient, wherein said second compound can enter opruriceptores nociceptors tra can enter opruriceptores nociceptors via said receiver forming cuanvés channels of said receiver channel formation when said receptor is activated, wherein dichosegunddo said receptor is activated, in which dichosegundo compound : i) inhibits channels regulated or compound sodium: i) inhibits sodium channels voltage, in particular wherein said segundopor voltage, in particular wherein said second compound is QX-314, Nmetilprocaína, QX-222, N -oc compound is QX-314, Nmetilprocaína, QX-222, N-octyl-guanidine, 9-aminoacridine, pancuronium, or otratil-guanidine, 9-aminoacridine, pancuronium, or other molecule of molecular weight 500 Dalton menorque, c molecule menorque 500 Dalton molecular weight, positively charged sodium channels inhibits rargada positively inhibiting sodium channels voltage when present inthe integulados voltage when est to present inthe interior of the cell or ii) is CERM 11888 (bepridiloerior cell or ii) is CERM 11888 (quaternary bepridil) or iii) is a quaternary amine derivati
