Disclosed is a family of intranasal spray dispensers for administering uniformlow doses of desmopressin so as toachieve safe antidiuresis in human patients. The dispensers of the inventionmay be used in the treatment of nocturia, primarynocturnal enuresis, incontinence, urinary frequency, diabetes insipidus, orany disease or syndrome where desmopressin therapy isuseful or where safe temporary suppression of urine production may lead tobeneficial health effects or increased convenience invoiding control.