The present invention relates to a pharmaceutical composition and functional food for preventing and treating restenosis which contains a lactic acid bacteria fermented product of a natural extract, more specifically a lactic acid bacteria fermented product of soshihotang. The soshihotang is a hot-water extract of bupleurum, scutellaria, ginseng, Glycyrrhizae radix, pinellia, ginger, and Zizyphus jvjuba. [Reference numerals] (30) # 5 measuring equipment; (50) Central monitoring equipment; (AA) Power supply; (BB) Signal; (CC) #6 measuring equipment; (DD) #4 measuring equipment; (EE) #3 measuring equipment; (FF) #2 measuring equipment; (GG) #1 measuring equipment본 발명은 혈관재협착의 예방 또는 치료에 효과적인 천연물 추출물의 유산균 발효물로서, 더 자세하게는 소시호탕의 유산균 발효물을 유효성분으로 함유하는 혈관재협착의 예방 또는 치료용 약학적 조성물 및 건강기능식품에 관한 것이다.