Substituted spiro-amide compounds corresponding to formula I in which R5 through R8, D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor.L'invention concerne des composés spiroamides substitués, leurs procédés de préparation, des médicaments contenant ces composés, ainsi que l'utilisation des composés spiroamides substitués pour la préparation de médicaments.