A device for priming and venting a hazardous drug within an intravenous administration set (10). The device includes various access ports (42, 26, 86) and fluid channels (50, 150) to permit direct injection of a hazardous drug into the fluid reservoir (24), while eliminating the possibility of undesirable exposure to the hazardous drug. The device further includes priming and flushing ports to enable flushing of a hazardous drug from the system following an infusion procedure.
