QIN MINMIN,Qin Minmin,HENSTRAND JOHN M.,Henstrand John M.,ZECHERLE GARY N.,Zecherle Gary N.,WENDT DAN J.,Wendt Dan J.,CHAN WAI-PAN,Chan Wai-Pan,CHEN LIN,Chen Lin,FITZPATRICK PAUL A.,Fitzpatrick Paul A
申请号：
SI200332419
公开号：
SI2327414T1
申请日:
2003.11.07
申请国别(地区):
SI
年份:
2015
代理人:
摘要：
The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N -acetylgalactosamirie-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N -acetylgalactosamine-4-sulfatase including MPS Vl and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
