TRANSFERT D'UN GENE DANS DES CELLULES SOUCHES EPITHELIALES DES VOIES RESPIRATOIRES VIA UN VECTEUR LENTIVIRAL PSEUDOTYPE AVEC UNE PROTEINE DE SPICULE DE VIRUS ARN OU VIRUS ADN
MITOMO, KATSUYUKI,INOUE, MAKOTO,IWASAKI, HITOSHI,HASEGAWA, MAMORU,ALTON, ERIC W.,GRIESENBACH, UTA
申请号：
CA2627485
公开号：
CA2627485C
申请日:
2006.10.27
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
A gene is successfully transferred into airway epithelial stem cells by usinga monkey immunodeficiency virus vector having been pseudotyped with Sendaivirus envelope glycoproteins F and HN. This gene transfer into airwayepithelial stem cells with the use of the vector as described above is usefulin gene therapy for a hereditary respiratory disease such as cystic fibrosis.Moreover, it becomes possible to select a respiratory organ such as the lungas a tissue that is capable of producing and supplying a protein deficient ina hereditary disease.
