Problem to be solved: to provide a heterocyclic derivative compound useful to inhibit plasma kallikrein and a pharmaceutical composition comprising the compound.A compound having the structure of formula (I) or its pharmaceutically acceptable salt.The compounds and compositions serve in the treatment of diseases involving inhibition of plasma kallikrein, such as vascular edema.No selection【課題】血漿カリクレインを阻害するのに役立つ複素環誘導体化合物と上記化合物を含む医薬組成物の提供。【解決手段】式(I)の構造を有する化合物またはその薬学的に許容可能な塩。当該化合物と組成物は、血管浮腫などの血漿カリクレインの阻害が関与している疾患の処置に役立つ。【選択図】なし