Embodiments of the disclosed technology are directed to a method for combining seed priming and vacuum infiltration to facilitate deep penetration of chemicals or other substances into seeds. By combining the two processes, the germination process of seeds can be started allowing a relatively lengthy period of disinfection. The lengthy period of disinfection under vacuum provides maximum penetration into the seed in order to eradicate diseases occurring deep inside the seed. Any type of seed priming may be used in the disclosed method, including, but not limited to, osmopriming, matrix priming, or hydropriming. Further, any type of seed may be treated, including most vegetable crops, ornamentals, and agronomic crops.
