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SMALL MOLECULE INHIBITORS OF BCL-2 ASSOCIATED DEATH PROMOTER
专利权人:
UNIVERSITY OF MYSORE;BANGALORE UNIVERSITY;NATIONAL UNIVERSITY OF SINGAPORE
发明人:
BASSAPPA SALUNDI,MOHAN CHAKRABHAVI DHANANJAYA,PETER EDWARD LOBIE,RANGAPPA KANCHUGARAKOPPAL SUBBEGOWDA,SHOBITH RANGAPPA,SRINIVASA VENKATACHALAIAH,VIJAY KUMAR PANDEY
申请号:
BR112019022015
公开号:
BR112019022015A2
申请日:
2018.04.18
申请国别(地区):
BR
年份:
2020
代理人:
摘要:
the invention relates to compounds of general formula (i): wherein r1, n, r2a, r2b and r3 are as defined herein. the compounds are inhibitors of death-promoting phosphorylation associated with bcl-2 (bad) and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer.a invenção refere-se a compostos de fórmula geral (i): em que r1, n, r2a, r2b e r3 são como aqui definidos. os compostos são inibidores de fosforilação de promotor de morte associado a bcl-2 (bad) e têm atividade antiapoptótica e são úteis no tratamento de câncer, particularmente câncer de mama, câncer endometrial, câncer de ovário, câncer de fígado, câncer de cólon, câncer de próstata ou câncer de pâncreas.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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