The present invention provides novel anti-Glypican-1 antibodies and methods for using the same. The present invention provides an anti-Glypican-1 antibody having intracellular translocation activity. Such activity was not seen with the conventional anti-Glypican-1 antibody. Utilizing the activity of the antibody of the present invention to translocate into cells, the present invention can be used for various therapeutic uses which have not been expected in the past. The present invention also provides a composition for preventing or treating Glypican-1 positive cancer, comprising a complex of a substance that binds to Glypican-1 (for example, an anti-Glypican-1 antibody) and a drug having cytotoxic activity. Also provide.本発明は新規抗Ｇｌｙｐｉｃａｎ－１抗体およびその利用法を提供する。本発明は、細胞内移行活性を有する抗Ｇｌｙｐｉｃａｎ－１抗体を提供する。このような活性は従来の抗Ｇｌｙｐｉｃａｎ－１抗体では見られなかった。本発明の抗体の細胞内移行活性を利用して、本発明は、従来では想定されなかった様々な治療用途に使用され得る。本発明はまた、Ｇｌｙｐｉｃａｎ－１に結合する物質（例えば、抗Ｇｌｙｐｉｃａｎ－１抗体）と細胞傷害活性を有する薬剤との複合体を含む、Ｇｌｙｐｉｃａｎ－１陽性がんを予防または治療するための組成物も提供する。
