BUTLER, THOMAS,CHO, AESOP,KIM, CHOUNG U.,SAUNDERS, OLIVER L.,ZHANG, LIJUN,PARRISH, JAY
申请号：
CA2722177
公开号：
CA2722177C
申请日:
2009.04.22
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl,imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinylnucleosides ofFormula (I), nucleoside phosphates and prodrugs thereof, wherein the l'position of thenucleoside sugar is substituted, and wherein each of X1 or X2 is independentlyC-R10 orN. The compounds, compositions, and methods provided may be useful for thetreatmentof Flaviviridae virus infections, particularly hepatitis C infections.(see formula I)
