PURPOSE: A cosmetic composition using Sargassum extract is provided to effectively penetrate hydrophilic physiologically active substances into the skin and to maximize functionality. CONSTITUTION: A cosmetic composition which promotes skin penetration of hydrophilic physiologically active substances contains: one or more among lauric acid and lauric acid derivatives, methyl pyrrolidone, ethyl alcohol, the hydrophilic physiologically active substances, and Sargassum extract with low phototoxicity. The lauric acid derivatives are lauric acid alcohol, lauric acid amine, lauric acid PEG-12, lauric acid sucrose, or lauric acid glycerin.본 발명은 광독성이 낮은 모자반 추출물을 이용하여 피부투과성이 낮은 친수성 생리활성물질의 피부투과를 촉진하는 화장료 조성물에 관한 것이다.