Compositions containing natural and botanical extracts for use in inhibiting one, two, or three of (a) - (c): (a) demethylation of PP2A by PME-1 methylesterase (b) formation of free radicals and reactive oxygen species and/or (c) inflammation. These compositions include an extract of one or more botanicals selected from the group consisting of: juniper berry fruit, schisandra fruit, strawberry fruit, avocado seeds, black raspberry seeds, blueberry seeds, celery seeds, cranberry seeds, fennel seeds, grape seeds, guarana seeds, red raspberry seeds, maca root, goldenseal root, turmeric root, magnolia bark, pygeum bark, red raspberry leaf, almond, cocoa powder, Echinacea angustifolia, prickly pear cactus and walnut.本發明提供含有天然及植物萃取物之組合物,其用於抑制(a)-(c)中之一者、二者或三者:(a)藉由PME-1甲基酯酶之PP2A之去甲基化反應;(b)自由基及反應性氧物質之形成;及/或(c)發炎。該等組合物包括一或多種選自由以下組成之群之植物藥材的萃取物:杜松子果、五味子果、草莓果、鱷梨籽、黑樹莓籽、藍莓籽、芹菜籽、苔莓籽、茴香籽、葡萄籽、瓜拿納籽(guarana seed)、樹莓籽、瑪卡根(maca root)、白毛茛根、薑黃根、厚樸、臀果木樹皮(pygeum bark)、樹莓葉、杏仁、可可粉、狹葉紫錐花(Echinacea angustifolia)、仙人掌及胡桃。
