Christian Glogard,Dirk-Jan in't Veld,Dirk-Jan int Veld
申请号：
US13582790
公开号：
US20130004433A1
申请日:
2011.03.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention relates to a process for the preparation of a diagnostic X-ray composition. The composition comprises a non-ionic X-ray contrast agent in a pharmaceutically acceptable carrier. More particularly, the invention relates to a process for secondary production of X-ray compositions comprising X-ray contrast agents with a high dissolution temperature. When using the process of the invention, precipitation is avoided and degradation of the contrast agent is reduced. The process of the invention includes heat treatment of iodinated X-ray contrast agents at low pH.
