The invention discloses biologically active ingredient(s) selected from 7 hydroxyfrullanolide its analogs the extract(s) and fraction(s) standardized to 7 hydroxyfrullanolide or its analogs or both or mixtures thereof or their composition(s) for the prevention control and treatment of one or more obesity overweight metabolic syndrome diabetes and other metabolic disorders or for producing lean body mass in a warm blooded animal in need thereof.