The application provides a conjugate or a pharmaceutically acceptable Salt thereof, comprising a polypeptide Synthetic Formula (1): Q - R - P - R - L - C - H - K - G - C - P - (NIE) * (1 - f) or an amide or Ester thereof； and a Fatty Acid selected from the compounds of formula (2) and (3),When the Fatty Acid is covalently attached to the n-terminus of a Peptide by carboxylic acid functionalities, optionally through a polyethylene glycol Linker and the two cysteine amino acids marked with * are a Link disulf URO between its side chain thiol functionalities. The Conjugates are APJ receptor agonists.It also relates to a method for the manufacture of the Conjugates of the present and their Therapeutic uses, including the Treatment or prevention of acute decompensated Heart Failure (ICAD), Chronic Heart Failure, atrial fibrillation, pulmonary hypertension syndrome Brugada Syndrome, ventricular tachycardia, hypertension, atherosclerosis, restenosisIschemic cardiovascular diseases, cardiomyopathy, Cardiac fibrosis, arrhythmia, Water Retention (including diabetes, gestational diabetes, obesity. Peripheral arterial disease, Stroke, transient ischemic attacks, Traumatic Brain Injury, Amyotrophic lateral sclerosis, Burns (including sunburn) and preeclampsia.This also provides a combination of pharmacologically Active agents and a Pharmaceutical composition.La solicitud proporciona un conjugado o una sal farmacéuticamente aceptable del mismo, que comprende un polipéptido sintético de fórmula (1): Q-R-P-R-L-C*-H-K-G-P-(NIe)-C*-F (1) o una amida o éster del mismo； y un ácido graso seleccionado de los compuestos de fórmula (2) y (3), en el que dicho ácido graso está unido covalentemente al extremo N-terminal del péptido a través de una de sus funcionalidades de ácido carboxílico, opcionalmente a través de un enlazador de polietilenglicol y en el que los dos aminoácidos de cisteína marcados con * forman un enlace disulfuro entre las funcionalidades tiol de su cadena lateral. Los co
