Antibody drug conjugates (ADC's) that bind to 161P2F10B protein are described herein. 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.本文描述結合至161P2F10B蛋白之抗體藥物結合物(ADC)。161P2F10B顯示在正常成年人組織中組織特異性表現,且在表I中所列之癌症中異常表現。因此,本發明之ADC提供一種用於治療癌症之治療組合物。