可作爲激酶抑制劑之新穎環取代Ｎ－吡啶基醯胺农业专利-农业专业知识服务系统

发明人:: BURGER, MATTHEW,柏格　马修,柏格　馬修,DRUMM, JOSEPH III,卓安　乔瑟夫　三世,卓安　喬瑟夫　三世,NISHIGUCHI, GISELE,尼希古奇　吉塞尔,尼希古奇　吉塞爾,RICO, ALICE,瑞可　艾莉丝,瑞可　艾莉絲,SIMMONS, ROBERT LOWELL,西蒙斯　罗伯特　罗威,西蒙斯　羅伯特　羅威,TAFT, BENJAMIN,塔夫特　班杰明,塔夫特,柏格马修,柏格馬修,卓安乔瑟夫三世,卓安喬瑟夫三世,尼希古奇吉塞尔,尼希古奇吉塞爾,瑞可艾莉丝,瑞可艾莉絲,西蒙斯罗伯特罗威,西蒙斯羅伯特羅威,塔夫特班杰明

摘要：: The present invention provides a compound of formula (A): as described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by PIM kinase using the compounds of Formula A, and pharmaceutical compositions comprising such compounds.本發明提供一種如本文所述之式(A)化合物，及其醫藥學上可接受之鹽、對映異構體、旋轉異構體、互變異構體或外消旋體。亦提供使用該等式(A)化合物及包含該等化合物之醫藥組合物治療由PIM激酶介導之疾病或病狀之方法。