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ПРОИЗВОДНЫЕ АЗАБИФЕНИЛАМИНОБЕНЗОЙНОЙ КИСЛОТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ DHODH
专利权人:
ALMIRAL;AL'MIRAL'; S.A.
发明人:
KASTRO-PALOMINO-LARIJA KHULIO-SESAR,TERRIKABRAS-BELART EHMMA,EHRRA-SOLA MONTSERRAT,NAVARRO-ROMERO EHLOISA,FONKERNA-POU SIL'VIJA,KARDUS-FIGERAS ARANSASU,LOSOJJA-TORIBIO MARIJA-EHSTRELLA,КАСТРО-ПАЛОМИНО-ЛАРИЯ Хулио-Сесар,ТЕРРИКАБРАС-БЕЛАРТ Эмма,ЭРРА-СОЛА Монтсеррат,НАВАРРО-РОМЕРО
申请号:
RU2010108261
公开号:
RU2481334C2
申请日:
2008.08.08
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention describes novel azabiphenylaminobenzoic acid derivatives, having the chemical formula:, where Ris selected from a group consisting of hydrogen atoms, halogen atoms, C-alkyl, C-cycloalkyl and -CF, Ris selected from a group consisting of hydrogen atoms, halogen atoms and C-alkyl group, Ris -COOR, where Ris selected from a group consisting of a hydrogen atom and linear or branched C-alkyl groups, Ris selected from a group consisting of a hydrogen atom and C-alkyl group; Ris selected from a group consisting of a hydrogen atom and a phenyl group, Gis a group selected from N and CR, where Ris selected from a group consisting of hydrogen atoms, halogen atoms, C-alkyl, C-cycloalkyl, -CPand C-aryl group, Gis a group selected from: - a hydrogen atom, hydroxy group, halogen atom, C-cycloalkyl group, C-alkoxy group and -NRR, where Ris C-alkyl group and Ris selected from a group consisting of C-alkyl group and C-alkoxy-C-alkyl group, or Rand Rtogether with the nitrogen atom with which they are bonded, form a saturated 6-8-member heterocyclic ring optionally containing one oxygen atom as an additional heteroatom, -monocyclic or bicyclic 5-10-member heteroatomatic ring containing one or more nitrogen atoms which are optionally substituted with one or more halogen atoms, and a phenyl group which is optionally substituted with one or more substitutes selected from halogen atoms, C-alkyl, hydroxy group, C-alkoxy group, C-cycloalkyl, C-cycloalkoxy group, cyano group, -CF, -OCF, -CONRR, oxadiazolyl, and where Rand Rare independently selected from a hydrogen atom, a linear or branched C-alkyl group, C-cycloalkyl group, or Rand Rtogether with a nitrogen atom with which they are bonded form a group of formula:, where n equals 0-3; or Gtogether with Rform a non-aromatic C-carbocyclic group or a C-aryl group, and pharmaceutically acceptable and N oxides thereof. Also described are pharmaceutical compositions containing said compounds and use thereof in
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