A syringe for use in vaccine reconstitution or rehydration has a barrel (1) having a plunger (2) in slidable and sealing engagement therein, and a piercing member (3) formed integrally with the barrel. The piercing member (3) has a bore (10) in communication with the distal end of the barrel, and a piercing point (12) and aperture (13) at its distal end. The distal end of the piercing member (3) has an external taper which comprises a male luer part (15) compatible with an infusion set. The length of the distal end of the piercing member (3) distally of a predetermined attachment diameter of the male luer part (15) is chosen so that it cannot fit a standard metal syringe needle, as the end of the piercing member (3) engages with another part of the metal needle before the female luer part on the needle reaches the attachment diameter. The syringe is easy to use for rehydration, but cannot be used for normal injections.
