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METHODS FOR TREATING INFLAMMATORY AUTOIMMUNE DISORDERS
专利权人:
Beth Israel Deaconess Medical Center; Inc.
发明人:
George C. Tsokos,Yuang-Taung Juang,Chun-Shin Hahn
申请号:
US13936792
公开号:
US20140161769A1
申请日:
2013.07.08
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention features a method of treating or reducing the likelihood of an inflammatory autoimmune disorder (e.g., systemic lupus erythematosus (SLE)) or a kidney disorder (e.g., glomerulonephritis) in a subject by administering an inhibitor of calcium/calmodulin-dependent protein kinase type IV (CaMKIV). The invention additionally features methods of diagnosing a subject with SLE or a kidney disorder by determining the level or biological activity of a CaMKIV nucleic acid or polypeptide in a sample from a subject. Also included in the invention are methods for identifying compounds that inhibit CaMKIV for the treatment of an inflammatory autoimmune disorder (e.g., SLE) or a kidney disorder (e.g., glomerulonephritis).
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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