Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.一種雙取代八氫吡咯并[3,4-c]吡咯化合物,係用於作為食慾激素受體調控劑。此等化合物可為有用的醫藥組合物以及治療方法用於治療經食慾激素活性調控的疾病狀態、失調與狀態,例如失眠。