1. Extruded from a melt dosage form with reduced interaction of a drug substance with alcohol, comprising: (a) an abused drug substance or drug substance having a dose dumping potential in alcohol； and (b) a matrix containing a polymer, copolymer, or a combination thereof, wherein the monomer is selected from the group consisting of: cellulose ether, cellulose ester, acrylic acid ester, methacrylic acid ester, vinyl alcohol, ethylene oxide and sodium alginate, where the specified matrix extruded from the melt； moreover, the dosage form has a reduced interaction of the drug substance with alcohol； where the dosage form is made with the possibility of oral administration to a person 3, 2 or 1 time per day.2. Extruded from the melt dosage form according to claim 1, where the drug substance is a salt or ester of verapamil, gamma-hydroxybutyrate, flunitrazepam or an opioid, where the opioid is selected from the group consisting of alfentanil, allylprodin, alfaprodin, anileridine, benzylmorphine, benzitramide, , butorphanol, clonitazene, codeine, cyclazocine, desomorphine, dextromoramide, deocin, diapromide, dihydrocodeine, dihydromorphine, dimenoxadol, dimefepanol, dimethylthiambutene, dioxafetyl butyrate, dipipanone , Eptazotsina, etogeptazina, etilmetiltiambutena, ethylmorphine, etonitazena, fentanyl, heroin, hydrocodone, hydromorphone, gidroksipetidina, isomethadone, ketobemidone, levallorphan, levofenatsilmorfana, levorphanol, lofentanil, meperidine, meptazinola, metazocine, methadone, metopon, morphine, mirofina, nalbuphine, nartseina , n�1. Экструдированная из расплава дозированная форма с уменьшенным взаимодействием лекарственного вещества со спиртом, содержащая:(a) злоупотребляемое лекарственное вещество или лекарственное вещество, обладающее в спирте потенциалом демпинга дозы； и(b) матрикс, содержащий полимер, сополимер или их комбинацию, где мономер выбирают из группы, состоящей из: простого эфира целлюлозы, сложного эфира целлюлозы, эфира акриловой кислоты, эф
