A composition, a method for administering an anti-seizure composition, and a method for treating a seizure are described. In an implementation, a composition comprises a peroxisome proliferator activated receptor gamma (PPARγ) antagonist that is administered to an individual, where the individual has been administered a ketogenic diet. In an implementation, a method for administering an anti-seizure composition comprises administering a ketogenic diet to an individual and concurrently administering a therapeutically effective dose of a peroxisome proliferator activated receptor gamma (PPARγ) antagonist to the individual In an implementation, a method for treating a seizure comprises administering a therapeutically effective dose of a peroxisome proliferator activated receptor gamma (PPARγ) antagonist to an individual on a ketogenic diet and suffering from seizures.
