ZHU, Yi,OLSEN, Ole,KHALILI, Jahan,XIA, Dong,JELLYMAN, David,BYKOVA, Katrina,ROUSSEAU, Anne-Marie,WANG, Camilla,GAO, Zeren,HUANG, Hui,LUNDY, Steven K.
申请号：
AU2019243453
公开号：
AU2019243453A1
申请日:
2019.03.26
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The application provides methods for generating a therapeutic composition. The method includes the steps of providing a cell material comprising a cytotoxic cell, incubating the cell material with a first GNC protein to provide an activated cell composition, wherein the activated cell composition comprises a first therapeutic cell, and formulating the activated cell composition to provide a therapeutic composition, wherein the therapeutic composition is substantially free of exogenous viral and non-viral DNA or RNA. The first GNC protein comprises a first cytotoxic binding moiety and a first cancer targeting moiety, wherein the first cytotoxic binding moiety has a specificity to a first cytotoxic cell receptor and is configured to activate the first cytotoxic cell, and wherein the first cancer targeting moiety has a specificity to a first cancer cell receptor. The first therapeutic cell comprises the first GNC protein bound to the cytotoxic cell through the first cytotoxic cell receptor.
