Computer-implemented method for determining an interest of applying a Quality Assessment (QA) procedure to a treatment plan in radiation therapy and comprising the steps of: (i) receiving information relating to said treatment plan; (ii) receiving information relating to a reference treatment plan that complies with a quality criterion; (iii) obtaining a dose distribution resulting from said reference treatment plan and/or a parameter of said reference treatment plan; (iv) obtaining a dose distribution resulting from said treatment plan and/or a parameter of said treatment plan; (v) comparing said dose distribution resulting from said treatment plan with said dose distribution resulting from said reference treatment plan, and/or said parameter of said treatment plan with same parameter of said reference treatment plan; (vi) from said comparison of step v, determining an interest of applying a QA procedure to said treatment plan.