United States Department of Veterans Affairs;University of Maryland Baltimore
发明人:
Simard, J. Marc,Chen, Mingkui
申请号：
AU2011201252
公开号：
AU2011201252B2
申请日:
2011.03.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011201252B220121206.pdf#####A BSTRACT A composition comprising a novel Ca2-activated, [ATP]-sensitive nonspecific cation (NCcaATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling- The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described.
