The disclosure relate to isolated compounds, extracts and compositions thereof, and methods of using of the same, to treat neurodegenerative disorders and/or improve brain health. In certain embodiments, said compounds are pomegranate flavonoids. The flavanoids disclosed as medicaments include punicalin, pedunculagin, tellimagrandin, corilagin, granatine A, granatine B, terminalin, gallagyldilactone, punicalagin and compounds of formula I. Conditions which may be treated include: cognitive disorders, neurodegenerative disorders, amyloidosis-related conditions, amyotrophic lateral sclerosis (ALS), Huntington&rsquo；s disease, Parkinson&rsquo；s disease, Down syndrome, cognitive impairment, memory impairment, attention impairment, reaction time impairment, and learning impairment.
