PROBLEM TO BE SOLVED: To provide a medical drug including drugs decomposable in an acid solution and keeping the quality stability of a drug solution, which is suitable for a long-term preservation even if it has a form of prefilled syringe storing a neutral or basic non-buffer solution.SOLUTION: The neutral or basic non-buffer solution containing a medical drug decomposable in the acid solution is stored in a gas-permeable container including a rubber member and a synthetic resin member, and the gas-permeable container is packed with a gas-nonpermeable package, and the medical drug has a means for removing carbon dioxide in a space between the gas-nonpermeable package and the gas-permeable container.COPYRIGHT: (C)2009,JPO&INPIT【課題】酸性溶液中で分解する医薬を含む、中性ないし塩基性の非緩衝性薬液を収容したプレフィルドシリンジの形態であっても、薬液の品質の安定性が保たれ、当該薬液の長期間の保存に適した医薬品製剤を提供する。【解決手段】酸性溶液中で分解する医薬を含む、中性ないし塩基性の非緩衝性薬液が、ゴム製の部材と合成樹脂製の部材とを含むガス透過性容器に収容され、さらに前記ガス透過性容器がガス非透過性の包装体で包装されてなる医薬品製剤であって、前記ガス非透過性の包装体と前記ガス透過性容器との間隙部に二酸化炭素を除去する手段を備える医薬品製剤。【選択図】図1
