Provided is a composition that is useful for treating acne, and which has been found to reduce and/or eliminate acne outbreaks or reduce the severity thereof. The composition includes mangosteen and curcumin. At least a portion of the mangosteen and curcumin can be provided in the form of extracts thereof. The composition can optionally include other components such as guggul, guggul extracts, thyme, thyme extracts, piperine, vitamin B5, vitamin B6, zinc, beta glucans, and green tea extracts. The composition can be provided as an oral administration unit such as a pill or capsule. Also provided is a method of treating acne by ingesting an effective amount of the composition described herein.
