STAFFORD, Jeffrey A.,VEAL, James M.,MCBRIDE, Christopher,TRZOSS, Llynnie Lin
申请号：
CL2019001988
公开号：
CL2019001988A1
申请日:
2019.07.15
申请国别(地区):
CL
年份:
2019
代理人:
摘要：
N provides compounds that are effective in inhibition and amperage； oacute； n provides a flammable substance, such as NLRP3. Tami amp compounds； eacute； n is effective in modules and amps； oacute； n is effective in interlequine. The transmitted compounds are molecular pesos, physicochemical properties and amperes； Iacute； micas； and ideal lipophilic properties, all of which are properties and amperes； Iacute； statistics that help achieve therapeutic and amperometric effects； eacute； usefulness and reduce unintended effects. The invention provides compounds of F amp, oacute and N； oacute, rmula I, salt, F amp, Aacute, rmacos, solvatos, hydrate, is amp, oacute and Meros,O taut amp； oacute； Meros pharmaceutical amp； eacute； accepted alternative C1-C6 tar group: R1 selected from alternative c1-c6alquinio alternative c1-c6axyl, alternative c1-c6axy tar group, - (CH2) m-ch3. lt； / P gt；<；p>； THE PRESENT DESCRIPTION IS RELATED TO NOVEL COMPOUNDS OF SULFONILUREA AND SULFONIL THIOUREA RELATED COMPOUNDS AND COMPOUNDS AND THEIR USE TO TREAT A ILLNESS-SENSITIVE CONDITION OF CITOQUIN 1. AND IL-18, NLRP3 MODULATION OR INHIBITION OF NLRP3 ACTIVATION OR RELATED COMPONENTS OF THE INFLAMMATORY PROCESS. <；/p>；<；p>；LA PRESENTE DESCRIPCIÓ；N PROVEE COMPUESTOS QUE SON EFICACES EN LA INHIBICIÓ；N DE UN INFLAMASOMA, TAL COMO EL INFLAMASOMA NLRP3. LOS COMPUESTOS TAMBIÉ；N SON EFICACES EN LA MODULACIÓ；N DE INTERLEUQUINAS. LOS COMPUESTOS DIVULGADOS TIENEN PESOS MOLECULARES, PROPIEDADES FISICOQUÍ；MICAS, Y LIPOFILICIDAD DESEABLES, LAS CUALES SON CARACTERÍ；STICAS QUE AYUDAN A CONSEGUIR EFICACIA TERAPÉ；UTICA Y DISMINUIR LOS EFECTOS NO DESEADOS. LA PRESENTE INVENCIÓ；N PROVEE COMPUESTOS DE FÓ；RMULA I, Y SALES, FÁ；RMACOS, SOLVATOS, HIDRATOS, ISÓ；MEROS, O TAUTÓ；MEROS FARMACÉ；UTICAMENTE ACEPTABLES DE LOS MISMOS, DONDE: R1 SE SELECCIONA ENTRE EL GRUPO QUE CONSISTE EN C1-C6ALQUILO OPCIONALMENTE SUSTITUID
