The present invention relates to a proton pump inhibitor or a pharmaceutically acceptable salt thereof for the treatment of skin diseases in canine patients. The invention also relates to improving the quality of life, improving the general health condition as well as preventing secondary infections in canine patients suffering from skin diseases. Moreover, the present invention also relates to a pharmaceutical composition for topical administration, preferably for use in a method of treating skin diseases and/or improving the general health condition in canine patients, wherein such pharmaceutical formulation comprises a proton pump inhibitor or a pharmaceutically acceptable salt thereof and one or more excipients.