The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula (I) wherein the dashed line indicates the presence or absence of a bond, the hatched wedge indicates the alpha (down) configuration, and the solid triangle indicates the beta (up) configuration B is a single, double, or triple covalent bond n is 0-6 X is CH2, S or O Y is any pharmaceutically acceptable salt of C02H, or C02R, CONR2, CONHCH2CH20H, CON(CH2CH2OH)2,CH2OR, P(O)(OR)2, CONRSO2R, SONR2, or formula (Ia) R is H, C1-6 alkyl or C2-6 alkenyl R<2> and R<3> are C1-6 linear alkyl which may be the same or different, and may be bonded to each other such that they form a ring incorporating the carbon to which they are commonly attached.
